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Have you heard of Dr. Ben Lynch, author of Dirty Genes?  


I'm a big fan and an Affiliate with his company called Seeking Health.  I'm excited to share some really great products with you that are optimized for those with an MTHFR variant. In full disclosure, I do receive a commission on any sales made through my Affiliate link.  However, I believe so strongly in what this company is about that it doesn't feel like I'm "selling" anything at all!  Any product recommendations I make are due to my full belief in their effectiveness and quality.  As always, please check with your physician before making any changes to your supplement regimen.  


Below are my top 20 Seeking Health products I think you'd be interested in.  If you're looking for something you don't see here, please check out the full Seeking Health website by clicking the link above.  


Methylate Chewable

I am so excited about the concept of this product and to share it with you!  Methylate Chewable contains a low dose of everything you need to gently encourage methylation on a daily basis.  This product contains methylfolate plus co-factors necessary for methylation, including riboflavin, niacin, vitamin B6, vitamin B12, choline, magnesium, zinc, and molybdenum. It's a perfect solution for those who may be sensitive to more powerful formulas.


Active B12 with L-5-MTHF

This product is great for those who need more B vitamins than their multivitamin offers.  It delivers a therapeutic dose of active B12 and methylfolate in the form of L-5-MTHF (a highly bioavailable form). Lozenges that dissolve in the mouth are believed to bypass the GI tract and offer superior absorption.  This product isn't recommended if you can not tolerate methylated B vitamins well. See the next product listing if that's you. 


Hydroxo B12 with Folinic Acid

This product is the right fit for you if you need more B vitamins than your multivitamin provides, but can't tolerate them in their methylated forms.   It offers a bioavailable and therapeutic dose of B12 in the form of hydroxocobalamin and folate in the form of folinic acid.  Lozenges that dissolve in the mouth are believed to bypass the GI tract and offer superior absorption. 


Multivitamin One

This one-a-day multivitamin contains everything you need for daily support, including active methylated forms of folate and B12!  This is a great multi-vitamin option for anyone who can tolerate methylated B vitamins.  If that's not you, please see the non-methylated multivitamin formula below. 


Optimal Multivitamin Minus One

Looking for a great multivitamin that contains bioavailable vitamin B9, but can't tolerate methylfolate well?  This product is your solution!  This multivitamin is the same product as the multivitamin featured in the previous listing, except it contains bio-available non-methylated B vitamins, including folate in the form of folinic acid.


Optimal Prenatal

This product is the ultimate prenatal vitamin for a mommy-to-be MTHFR!  It contains both methylated and non-methylated forms of vitamin B9 (folate), as well as a wide variety of nutrients that are critical during pregnancy.  This formulation also contains ginger, which helps to aid digestion and prevent nausea.  For those who have difficulty swallowing capsules, other formulations are available on the full Seeking Health website.


Kids Multivitamin

Kids Multivitamin is the perfect product for little MTHFRs! It contains essential vitamins, minerals, and trace elements that your little one needs to grow and thrive and is free of iron and copper. And of course, it contains B vitamins in their active forms, including folate and vitamin B12.  


B Complex Plus

This product delivers eight B vitamins, including the active forms of folate, vitamin B12, riboflavin, and B6.  It also includes choline, which is a methylation co-factor, assisting in optimal absorption.  


Optimal Liposomal Glutathione Plus

As you may be aware, glutathione is the body's master antioxidant and those with an MTHFR variant are susceptible to a deficiency in this critical compound.  There are several ways of boosting glutathione, one of which is direct supplementation.  This product delivers glutathione in the highly absorbable liposomal form, along with important co-factors that help to support it, including riboflavin, selenium, and molybdenum, as well as PQQ.


ProBiota HistaminX

This probiotic supplement is all about gut health!  Each capsule contains several healthy bacteria strains, none of which are known to increase histamine in the gut (excess histamine causes certain kinds of allergic reactions and digestive distress from ingested foods).  This product is a fan favorite and one of Seeking Health's best sellers!    


Liver Nutrients

Being a healthy MTHFR is all about supporting the liver!  This product contains a blend of 5 key ingredients that does just that, as well as support the body's free radical defense system and production of glutathione.  The key players in this product are milk thistle extract, N-Acetyl-Cysteine, Taurine, Betaine Anhydrous, and Alpha-Lipoic Acid. 


NAC (N-Acetyl-L-Cysteine)

NAC is a key player in the production of glutathione.  While the previous listing (Liver Nutrients) contains NAC, this product offers it in a solitary, more powerful dose.  NAC is important in the health of many bodily systems and supports the defense of free radicals.


Optimal Liposomal Vitamin C Plus

With the combination of a highly absorbable form of Vitamin C and a powerful bioflavonoid blend, this product offers excellent immune system support for someone with an MTHFR variant.  This product comes in liquid liposomal form (for ultimate absorption) and offers a pleasant taste as well.


Optimal Detox Vanilla

Optimal detox is basically a super protein powder that also aids in creating a healthy GI system and managing inflammation.  This product is vegetarian-friendly and boasts a variety of nutrients, including a pea/rice protein formula, activated B vitamins, phytonutrients, and a bioflavonoid blend.  



This product delivers a powerful dose of dietary indoles, a type of compound present in cruciferous vegetables, such as broccoli and cabbage.  Dietary indoles help the body to metabolize estrogen in a healthy way and to potentially prevent certain types of cancer. While no supplement should replace a healthy diet, this product can help to deliver these important compounds that may be difficult to get in adequate amounts through diet alone.


Histamine Block​

Histamine Block contains a patented enzyme formula that delivers 10,000 HDU of diamine oxidase (DAO).  DAO is the enzyme primarily responsible for the breakdown of ingested histamine.  While the ProBiota HistaminX product does not contribute to histamine production, this product will actually help to actively break it down.


Adrenal Nutrients

Adrenal Nutrients contains a powerful blend of Vitamin C, zinc, and pantothenic acid (vitamin B5), as well as a blend of plant extracts and herbs that support healthy adrenal function.  While perpetual stress negatively affects the adrenal system, Adrenal Nutrients is designed to help the body respond to stress in a more healthy way. 



S-adenosyl-L-methionine (SAMe) is the body's primary methyl donor. SAMe plays an important role in methylation, production of glutathione, and overall mood and sense of well-being.  While many find relief from methylation-related depression and anxiety with this supplement, it's important to note that you should consult your physician before taking this supplement to manage such symptoms.



While commonly thought of as a bodybuilding supplement, creatine is a great supplement for a MTHFR! It offers indirect encouragement of methylation by supporting the liver, as well as the brain.  This formula also contains magnesium for increased methylation support.  


Dirty Genes Book by Dr. Ben Lynch

This is the book that made Dr. Ben Lynch a household name in the world of holistic health!  It's all about optimizing your genetic health and even learning how to turn problematic genes "off" through healthy diet and lifestyle, a process also known as epigenetics. Through reading this book, you'll learn more about, not only the MTHFR gene, but several other common gene SNPs that cause all kinds of health problems. More importantly, you'll learn what to do about them.  I can personally attest that I absolutely loved this book and everything it had to offer!

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