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Laughing Gas + MTHFR = Not Funny


Ain't nothing funny about this. Did you know that laughing gas (nitrous oxide) is particularly dangerous for certain populations of people, including those with the MTHFR gene mutation? Let's break down why...


To make a long scientific explanation short, nitrous oxide interferes with methylation. If you're privy to the complications of having the MTHFR variant, you'll know that having this gene mutation means already having inefficient methylation. Nitrous oxide creates a byproduct called cobalamin, which essentially destroys Vitamin B12 in the body.


While someone without the MTHFR variant is able to detox this product from their system before severe damage is done, those with the MTHFR gene variant have trouble detoxing effectively. Because of this, cobalamin is given free reign to destroy Vitamin B12 and potentially cause life-threatening complications. Nitrous oxide has been connected with causing increased homocysteine levels, stroke, irreversible neurological impairment, and even death in those with this gene variant.


Here are some rules of thumb to follow:

-Avoid anesthesia as often as possible

-If you must use anesthesia, bring it to your doctor or dentist's attention that you have the MTHFR gene mutation and discuss safe options

-Detox prior to using anesthesia, therefore making the process of flushing the substance from your system more efficient


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